孙成宏，男，中药学博士研究生，副教授。主要研究方向为基于系统生物学的中药作用机制研究和中药新药开发。主持及参与了荆防颗粒/合剂、首荟通便胶囊、鼻渊通窍颗粒、脉络舒通丸等多个中药大品种的培育工作，在中药单体和复方的靶点发现、机制解析及新适应症开发等方向具有丰富的实践经验。主持山东省重点研发计划（竞争性创新平台）1项，山东省自然基金创新发展联合基金子课题1项，参与山东省自然科学基金企业先导联合基金项目1项，共发表论文60余篇，其中以第一作者或通讯作者在《J Ethnopharmacol》、《Int Immunopharmacol》、《Biomed Pharmacother》、《Int J Nanomedicine》等杂志发表SCI论文20余篇。申请国家发明专利17项，PCT专利3项，授权国家发明专利8项。获中华中医药学会科学技术奖一等奖1项，中国民族医药学会科学技术奖药物创新奖一等奖1项，山东省中医药行业科学技术奖一等奖1项，山东医药行业科学技术奖一等奖1项，临沂市技术发明二等奖1项，临沂市自然科学优秀学术成果奖一等奖1项，临沂市自然科学优秀学术成果奖三等奖1项。

主持或参加科研项目（课题）情况:

1. 山东省重点研发计划（竞争性创新平台），基于中药有效性与中药现代化关键技术融合创新的荆防败毒散及成方制剂系统性开发研究（2024CXPT074），2024.09.30-2027.09.30，主持，1600万元。

2. 山东省自然基金创新发展联合基金，中医经典名方“苍耳子散”现代成方制剂鼻渊通窍颗粒治疗鼻鼽的物质基础及作用机制研究（ZR2022LZY029），2023.12-2025.12，子课题负责人，50万元。

3. 山东省自然科学基金企业先导联合基金，用于治疗免疫性血小板减少症及化疗药导致的骨髓抑制的淫羊藿苷元的研究与开发（ZR2015QL002），2015.10-2017.12，参与，100万元。

近五年发表的代表性论文（“*”第一作者，“#”通讯作者）：

1. Kun Wang*, Mengmeng Shen*, Hongguang Tang*, Jidong Zhou, Yan Liu, Dejun Niu, Zhen Zeng, Lihong Pan#, Jingchun Yao#, Chenghong Sun#. Jingfang Granule promotes the tricarboxylic acid cycle to improve chronic fatigue syndrome by increasing the expression of Idh1 and Idh2. J Ethnopharmacol, 2025, 340: 119241.

2. Xiuwen Wang*, Lihong Pan*, Dejun Niu, Jidong Zhou, Mengmeng Shen, Zhen Zeng, Wenqiao Gong, Enhua Yang, Yunfeng Tang#, Guoliang Cheng#, Chenghong Sun#. Jingfang Granules alleviates the lipid peroxidation induced ferroptosis in rheumatoid arthritis rats by regulating gut microbiota and metabolism of short chain fatty acids. J Ethnopharmacol, 2025, 339: 119160.

3. Zhikang Wang*, Shujun Liu*, Shirong Li*, Fangjiao Wei, Xiaoyan Lu, Pan Zhao#, Chenghong Sun#, Jingchun Yao#. Jingfang Granules alleviates OVA-induced allergic rhinitis through regulating endoplasmic reticulum stress signaling pathway. J Ethnopharmacol, 2025, 338(Pt 1): 119039.

4. Fangjiao Wei*, Jidong Zhou*, Lihong Pan*, Mengmeng Shen, Dejun Niu, Zhen Zeng, Guoliang Cheng, Jingchun Yao#, Guimin Zhang#, Chenghong Sun#. Integrative microbiomics, proteomics and lipidomics studies unraveled the preventive mechanism of Shouhui Tongbian Capsules on cerebral ischemic stroke injury. J Ethnopharmacol. 2024 Oct 1;337(Pt 2):118874.

5. Yongxia Guan*, Lihong Pan*, Dejun Niu, Xin Li, Shirong Li, Guoliang Cheng, Zhen Zeng, Rujing Yue, Jingchun Yao, Guimin Zhang#, Chenghong Sun#, Hongjun Yang#. Mailuo Shutong pills inhibit neuroinflammation by regulating glucose metabolism disorders to protect mice from cerebral ischemia-reperfusion injury. J Enthnopharmacol, 2024, 335: 118621.

6. Mingfei Liu*, Yuanyuan Zhang, Linkui Deng, Lihong Pan, Xiaoyan Lu, Rujing Yue, Dejun Niu, Shirong Li#, Chenghong Sun#, Jingchun Yao#. Disorders of fatty acid metabolism and imbalance in the ratio of monounsaturated fatty acids promote the development of pulmonary fibrosis. Int Immunopharmacol, 2024, 139: 112671.

7. Xingxu Sun*, Haixin Xiang*, Zhong Liu, He Xiao, Xin Li, Wenqiao Gong, Lihong Pan, Lizhi Zhao, Jingchun Yao#, Chenghong Sun#, Guimin Zhang#. Jingfang Granules (荆防颗粒) alleviates bleomycin-induced acute lung injury through regulating PI3K/Akt/mTOR signaling pathway. J Enthnopharmacol, 2024, 318(Pt A): 116946.

8. Ruikun Wang*, Tianye Yang*, Qun Feng, Yujun Jiang, Xiaomei Yuan, Lizhi Zhao, Ning Liu, Zhong Liu, Yongkang Zhang, Luyao Wang, Guoliang Cheng, Jingchun Yao, Chenghong Sun#, Guimin Zhang#, Qinglong Gu#. Integration of network pharmacology and proteomics to elucidate the mechanism and targets of traditional Chinese medicine Biyuan Tongqiao granule against allergic rhinitis in an ovalbumin-induced mice model. J Enthnopharmacol, 2024, 318: 116816.

9. Chenghong Sun*, Ningning Cao*, Qingguo Wang*, Ning Liu, Tianye Yang, Shirong Li, Lihong Pan, Jingchun Yao, Li Zhang, Mingfei Liu, Guimin Zhang#, Xuefeng Xiao#, Changxiao Liu#. Icaritin induces resolution of inflammation by targeting cathepsin B to prevents mice from ischemia-reperfusion injury. Int Immunopharmacol, 2023, 116: 109850.

10. Mingfei Liu*, Shirong Li*, Ningning Cao, Qingguo Wang, Yuhao Liu, Qianqian Xu, Lin Zhang, Chenghong Sun#, Xuefeng Xiao#, Jingchun Yao#. Intestinal flora, intestinal metabolism, and intestinal immunity changes in complete Freud's adjuvant-rheumatoid arthritis C57BL/6 mice. Int Immunopharmacol. 2023, 125(Pt A): 111090.

11. Chenghong Sun*, Yongkang Zhang*, Mingfei Liu*, Zhong Liu, Lihong Pan, Hongbao Liang, Ning Liu, Shirong Li, Dejun Niu, Xiangzi Li, Bin Li, Lijuan Cui, Jingchun Yao#, Xuefeng Xiao#, Guimin Zhang#. Shouhui Tongbian Capsules induce regression of inflammation to improve intestinal barrier in mice with constipation by targeted binding to Prkaa1: With no obvious toxicity. Biomed Pharmacother, 2023, 161: 114495.

12. Shirong Li*, Jieyi Wu*, Ningning Cao, Qingguo Wang, Yuanyuan Zhang, Tianye Yang, Yu Miao, Lihong Pan, He Xiao, Mingfei Liu, Chenghong Sun#, Jingchun Yao#, Xuefeng Xiao#. Jingfang granules ameliorate inflammation and immune disorders in mice exposed to low temperature and high humidity by restoring the dysregulation of gut microbiota and fecal metabolites. Biomed Pharmacother, 2023, 165: 115050.

13. Ke Lv*, Mingyue Li*, Chenghong Sun*, Yu Miao, Yan Zhang, Yang Liu, Jianshuang Guo, Qing Meng, Jingchun Yao#, Guimin Zhang#, Jing Li#. Jingfang Granule alleviates bleomycin-induced acute lung injury via CD200-CD200R immunoregulatory pathway. J Enthnopharmacol, 2023, 311: 116423.

14. Xiangyu Zhuang*, Chenghong Sun*, Pengzhen Fu, Changhai Yu, Jie Jiang, Shuangshuang Wang, Xuefeng Xiao#, and Bin Wang#. Gram-Scale Synthesis of Loganetin from S‑(+)-Carvone. J Org Chem, 2023, 88: 5844−5851.

15. Jianwei Fan*, Yu Miao#, Yun Zhao, Yongxia Guan, Li Zhang, Lihong Pan, Qun Feng, Jingchun Yao, Chenghong Sun#. Icaritin inhibits oxidative stress in murine astrocytes by binding to Orai1 to block store-operated calcium channel. Chem Biol Drug Des, 2023, 101(4): 873–882.

16. Yunfeng Tang*, Lixin Sun*, Yun Zhao, Jingchun Yao, Zhong Feng, Zhong Liu, Guimin Zhang, Chenghong Sun#. UHPLC-ESI-QE-Orbitrap-MS based metabolomics reveals the antioxidant mechanism of icaritin on mice with cerebral ischemic reperfusion. Peer J, 2023, 11: e14483.

17. Chenghong Sun*, Hongbao Liang*, Yun Zhao, Shirong Li, Xiangzi Li, Xiaomei Yuan, Guoliang Cheng, Yongkang Zhang, Mingfei Liu, Yongxia Guan#, Jingchun Yao#, Guimin Zhang#. Jingfang Granules improve glucose metabolism disturbance and inflammation in mice with urticaria by up-regulating LKB1/AMPK/ SIRT1 axis. J Enthnopharmacol, 2023, 302(Pt A): 115913.

18. Hongbao Liang*, Chenghong Sun*, Zhong Feng, Xianzhen Wang, Lingpeng Kong, Feng Zhu, Jingchun Yao, Xiaomei Yuan, Zhong Liu, Guimin Zhang#, Feng Li#. Study on Integrated Pharmacokinetics of the Component-Based Chinese Medicine of Ginkgo biloba Leaves Based on Nanocrystalline Solid Dispersion Technology. Int J Nanomed, 2022,17: 4039-4057.

19. Yuyu Xu, Xiaoyan Lu, Li Zhang, Lijuan Wang, Guimin Zhang, Jingchun Yao, Chenghong Sun#. Icaritin activates Nrf2/Keap1 signaling to protect neuronal cells from oxidative stress. Chem Biol Drug Des, 2021, 97(1): 111-120.

20. Bingyuan Du, Li Zhang, Ying Sun, Guimin Zhang, Jingchun Yao, Mingmin Jiang, Lihong Pan, Chenghong Sun#. Phillygenin exhibits anti-inflammatory activity through modulating multiple cellular behaviors of mouse lymphocytes. Immunopharmacol Immunotoxicol, 2019, 41(1): 76-85.

获奖情况：

1. 基于中药现代化的中药颗粒剂产业化关键技术创新与生产体系的构建，中华中医药学会科学技术奖，一等奖，2022.11，13/15.

2、基于“以补治秘、畅舟通便”治疗理念的首荟通便胶囊创制与产业化，中国民族医药学会科学技术奖，药物创新奖一等奖，2023.10，4/15.

3、儿科痰热咳嗽兼食积证的小儿消积止咳颗粒开发与产业化，山东省中医药行业科学技术奖，一等奖，2023.12，3/15.

4、耦合气阴双补与泻热消痞的首荟通便胶囊创制与产业化，山东医药行业科学技术奖，一等奖，2022.01，6/10.

5、小儿消积止咳颗粒的研究与开发，临沂市技术发明奖，二等奖，2020.07月，4/10.

6、连翘苷元通过调节小鼠淋巴细胞的多种细胞行为而显示出抗炎活性，临沂市第十六届自然科学优秀学术成果奖，三等奖，2020.10，3/4（通讯）.

7、淫羊霍元对环磷既胺诱导的骨髓抑制小鼠造血功能的改善作用，临沂市第十五届自然科学优秀学术成果奖，一等奖，2018.09，1/4.

授权专利：

1. 赵志全，徐真真，孙成宏，牟丽丽. 淫羊藿苷元在制备治疗品学药物中的应用[P]. 中国, ZL201310648709.8, 2019-12-31.

2. 赵志全, 李涛, 李光艳, 孙成宏. 淫羊藿苷元在制备治疗或预防血小板减少症药物中的用途[P]. 中国,ZL201310493718.4, 2019-08-30.

3. 赵志全, 孙成宏, 王明智, 齐长鹏. 淫羊藿苷元在制备预防或治疗肺纤维化药物中的应用[P]. 中国,ZL201410505292.4,2019-08-13.

4. 张贵民, 姚景春, 吕金钢, 刘奋, 孙成宏. 连翘苷元在制备预防或治疗系统性红斑狼疮药物中的应用[P]. 中国, ZL201510703141.4, 2019-12-06.

5. 张贵民, 孙成宏, 刘艳松. 牛蒡子苷元在制备治疗脊髓损伤药物中的用途[P]. 中国, ZL201710211087.0, 2022-09-16.

6. 张贵民, 王升兰, 孙成宏. 含桥环的咪唑衍生物[P]. 中国, ZL201610510930.0, 2021-11-12.

7. 姜明敏，孙成宏，潘丽红.首荟通便胶囊的医药用途[P].中国, ZL 2021 1 0828042.4, 2024-06-07.

8. 孙成宏, 姚景春, 李红华. 一种中药组合物在制备治疗神经源性肺水肿药物中的用途[P]. 中国, ZL202111161272.6, 2024-06-14.